Debra A. Thompson, Ph.D.
Selected Publications
Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal NA, Kasus-Jacobi A. Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. Free Radic Biol Med 2009 Aug 14. [Epub ahead of print]
Chrispell JD, Feathers KL, Kane M, Brooks M, Khanna R, Kurth I, Hübner C, Gal A, Mears A, Swaroop A, Napoli JL,. Thompson DA. RDH12 activity and effects on retinoid processing in the murine retina. J Biol Chem 2009. doi:10.1074/jbc.M109. 020966.
Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, and Dhe-Paganon S. Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J Struct Biol 2009:165;88-96.
Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN, Jr., Thompson DA. Nrl-Knockout Mice Deficient in Rpe65 Fail to Synthesize 11-cis Retinal and Cone Outer Segments. Invest Ophthalmol Vis Sci 2008:49;1126-1135.
Kurth I, Thompson DA, Ruther K, Feathers KL, Chrispell JD, Schroth J, McHenry CL, Schweizer M, Skosyrski S, Gal A, Hubner CA. Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. Mol Cell Biol 2007:27;1370-1379.
Hemati N, Feathers KL, Chrispell JD, Reed DM, Carlson TJ, Thompson DA. RPE65 surface epitopes, protein interactions, and expression in rod- and cone-dominant species. Mol Vis 2005:11;1151-1165.
Thompson DA, Janecke AR, Lange J, Feathers, KL, Hubner, CA, McHenry CL et al. Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. Hum Mol Genet 2005:14;3865-75.
Janecke AR, Thompson DA, Utermann G, Becker C, Hübner CA, Schmid E, McHenry CL, Nair AR, Rüschendorf F, Heckenlively J, Wissinger B, Nürnberg P, Gal A. Mutations in a photoreceptor cell retinol dehydrogenase cause severe childhood-onset retinal dystrophy. Nat Genet 2004:36;850-854.
Thompson DA, Gal A. Vitamin A metabolism in the retinal pigment epithelium: Genes, mutations, and diseases. Prog Retin Eye Res 2003:22;683-703.
Thompson DA, McHenry CL, Li Y, Richards JE, Othman MI, Schwinger E, Vollrath D, Jacobson SG. and Gal A. Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2 with homoallelism for mutations in RPE65 or MERTK, Respectively. Am J Hum Genet. 2002:70;224-229.
Thompson DA, Li Y, McHenry CL, Carlson TJ, Ding X, Apfelstedt-Sylla E, Sieving PA, Gal A. Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. Nature Genet 2001:28;123-124.
Sieving, P.A., Chaudhry, P., Kondo, M., Provenzano, M., Wu, D., Carlson, T.J., Bush, R.A., and Thompson, D.A. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides mechanism for night blindness in isotretinoin therapy. Proc Natl Acad Sci (USA) 2001:98;1835-1840.
Gal A, Li Y, Thompson DA, Weir J, Orth U, Jacobson SG, Apfelstedt-Sylla E, Vollrath D. Mutations in MERTK, the human ortholog of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet 2000:26;270-271.
Gu S-m, Thompson DA, Srikumari CRS, Lorenz B, Finckh U, Nicoletti A, Murthy KR, Rathman M, Kumaramakckavel G, Denton MJ, Gal A. Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy. Nature Genet 1997:17;194-197.
