Terry J. Smith, M.D.
Selected Publications

Douglas RS, Naik V, Hwang CJ, Afifiyan NF, Gianoukakis AG, Sand D, Kamat S, Smith TJ. B cells from patients with Graves’ disease aberrantly express the IGF-1 receptor: Implications for disease pathogenesis. J Immunol 2008;181:5768-5774.

Tsui S, Naik N, Hoa N, Hwang CJ, Afifiyan NF, Sinha Hikim A, Gianoukakis AG, Douglas RS, Smith TJ. Evidence for an association between thyroid stimulating hormone and insulin-like growth factor 1 receptors: A tale of two antigens implicated in Graves’ disease. J Immunol 2008;181:4397-4405.

Smith TJ, Tsai CC, Shih M-J, Tsui S, Chen B, Han R, Naik V, King CS, Press C, Kamat S, Goldberg RA, Phipps RP, Douglas RS, Gianoukakis AG. Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid 2008;18:983-988.

Naik V, Khadavi N, Naik MN, Hwang C, Goldberg RA, Tsirbas A, Smith TJ, Douglas RS. Biologic therapeutics in thyroid-associated ophthalmopathy: Translating disease mechanism into therapy. Thyroid 2008;18:967-971.

Smith TJ, Douglas RS. Pathophysiology of Graves’ Orbitopathy. In: D. Albert, J. Miller, D. Azar, B. Blodi, eds. Albert and Jakobiec’s Principles and Practice of Ophthalmology, 3rd ed.  Philadelphia:Saunders-Elsevier, 2008:2913-2926.

Han R, Chen B, Smith TJ. Janus kinase-2 dampens the induction by IL-1b of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts: Evidence for divergent influence on the PGE2 biosynthetic pathway. J Immunol 2007;179:7147-7156.

Smith TJ. Editorial: Is a common therapy for autoimmune disease possible? Future Rheumatol 2007;2:333-335.

Smith TJ. Editorial: B cell depletion in Graves’ disease: The right answer to the wrong question? J Clin Endocrinol Metab 2007;92:1620-1622.

Douglas RS, Gianoukakis AG, Goldberg RA, Kamat S, Smith TJ. Circulating mononuclear cells from euthyroid patients with thyroid-associated ophthalmopathy exhibit characteristic phenotypes. Clin Exp Immunol 2007;148:64-71.

Douglas RS, Gianoukakis AG, Kamat S, Smith TJ. Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol 2007;178:3281-3287.

Chen B, Tsui S, Boeglin WE, Douglas RS, Brash AR, Smith TJ. IL-4 induces 15‑lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves’ disease: Evidence for anatomic site-selective action of TH2 cytokines. J Biol Chem 2006;281:18296-18306.

Gianoukakis AG, Douglas RS, King CS, Cruikshank WW, Smith TJ. IgG from patients with Graves’ disease induces IL-16 and RANTES expression in cultured human thyrocytes: A putative mechanism for T cell infiltration of the thyroid in autoimmune disease. Endocrinology 2006;147:1941-1949.

Smith TJ. Insights into the role of fibroblasts in human autoimmune diseases. Clin Exp Immunol 2005;141:388-397.

Chen B, Tsui S, Smith TJ. IL-1b induces IL-6 expression in human orbital fibroblasts: identification of an anatomic-site specific phenotype attribute relevant to thyroid-associated ophthalmopathy. J Immunol 2005;175:1310-1319.

Smith TJ. Novel aspects of orbital fibroblast pathology. J Endocrinol Invest 2004;27:246-253.