Howard R. Petty, Ph.D.
Selected Publications

• Sitrin RG, Sassanella TM, Petty HR. An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils. Am J Respir Cell Mol Biol 2011;44:205-12.
• Zhu A, Romero R, Huang JB, Clark A, Petty HR. Maltooligosaccharides from JEG-3 trophoblast-like cells exhibit immunoregulatory properties. Am J Reprod Immunol 2011;65:54-64.
• Yang D, Elner SG, Clark AJ, Hughes BA, Petty HR, Elner VM. Activation of P2X Receptors Induces Apoptosis in Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci 2011;52:1522-30.
• Clark AJ, Romero R, Petty HR. Improved detection of nicotinamide adenine dinucleotide phosphate oscillations within human neutrophils. Cytometry A 2010;77:976-82.
• Petty HR, Elner VM, Kawaji T, Clark A, Thompson D, Yang DL. A facile method for immunofluorescence microscopy of highly autofluorescent human retinal sections using nanoparticles with large Stokes shifts. J Neurosci Methods 2010;191:222-6.
• Xu Y, Madsen-Bouterse SA, Romero R, Hassan S, Mittal P, Elfline M, Zhu A, Petty HR. Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsia. Am J Reprod Immunol 2010;64:137-51.
• Zhu A, Romero R, Petty HR. Amplex UltraRed enhances the sensitivity of fluorimetric pyruvate detection. Anal Biochem 2010;403:123-5.
• Elfline M, Clark A, Petty HR, Romero R. Bi-directional calcium signaling between adjacent leukocytes and trophoblast-like cells. Am J Reprod Immunol 2010;64:339-46.
• Clark AJ, Petty HR. A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils. Cell Immunol 2010;261:153-8.
• Sitrin RG, Sassanella TM, Landers JJ, Petty HR. Migrating human neutrophils exhibit dynamic spatiotemporal variation in membrane lipid organization. Am J Respir Cell Mol Biol 2010;43:498-506.
• Zhu A, Romero R, Petty HR. A sensitive fluorimetric assay for pyruvate. Anal Biochem 2010;396:146-51.
• Clark AJ, Diamond M, Elfline M, Petty HR. Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosis. Cancer Immunol Immunother 2010;59:149-59.
• Zhu A, Romero R, Petty HR. An enzymatic fluorimetric assay for glucose-6-phosphate: application in an in vitro Warburg-like effect. Anal Biochem 2009;388:97–101.
• Field MG, Elner VM, Park S, Hackel R, Heckenlively JR, Elner SG, Petty HR. Detection of retinal metabolic stress resulting from central serous retinopathy. Retina 2009;29:11626.
• Yang D, Elner SG, Lin LR, Reddy VN, Petty HR, Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009;50:4998-5005.
• Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, noninvasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008;126:934-38.
• Madsen-Bouterse SA, Xu Y, Petty HR, Romero R. Quantification of O-GlcNAc protein modification in neutrophils by flow cytometry. Cytometry A 2008;73A:667-72.
• Clark AJ, Petty HR. Observation of calcium microdomains at the uropod of living morphologically polarized human neutrophils using flash lamp-based fluorescence microscopy. Cytometry A 2008;73:673-8.
• Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-60.
• Hinkovska-Galcheva VT, Clark A, Van Way SM, Huang JB, Hiraoka M, Abe A, Borofsky M, Kunkel RG, Shanley TP, Shayman JA, Lanni F, Petty HR, Boxer LA. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J Lipid Res 2008;49:531-42.
• Zhu A, Huang JB, Clark A, Romero R, Petty HR. 2,5-Deoxyfructosazine, a d-glucosamine derivative, inhibits T-cell interleukin-2 production better than d-glucosamine. Carbohydr Res 2007;342:2745-9.
• Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-72.
• Jarvis JN, Jiang K, Petty HR, Centola M. Neutrophils: The forgotten cell in JIA disease pathogenesis. Pediatr Rheumatol Online J 2007;5:13.
• Huang JB, Clark AJ, Petty HR. The hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells. Cell Immunol 2007;245:1-6.
• Petty HR. Fluorescence microscopy: Established and emerging methods, experimental strategies, and applications in immunology. Microsc Res Tech 2007;70:687-709.
• Sitrin RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR.Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol 2006;177:8177-84.
• Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 2006;8:R154.