Howard R. Petty, Ph.D.
Publications
Zhu A, Romero R, Petty HR. An enzymatic fluorimetric assay for glucose-6-phosphate: application in an in vitro Warburg-like effect. Anal Biochem 2009 [Epub ahead of print].
Clark AJ, Diamond M, Elfline M, Petty HR. Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosis. Cancer Immunol Immunother 2009 [Epub ahead of print].
Zhu A, Romero R, Petty HR. An enzymatic fluorimetric assay for glucose-6-phosphate: application in an in vitro Warburg-like effect. Anal Biochem 2009 [Epub ahead of print].
Field MG, Elner VM, Park S, Hackel R, Heckenlively JR, Elner SG, Petty HR. Detection of Retinal Metabolic Stress Resulting from Central Serous Retinopathy. Retina 2009 [Epub ahead of print].
Yang D, Elner SG, Lin LR, Reddy VN, Petty HR, and Elner VM. Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci 2009 [in press].
Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, noninvasive detection of diabetes-induced retinal metabolic stress. Arch Ophthalmol 2008;126:934-938.
Madsen-Bouterse SA, Xu Y, Petty HR, Romero R. Quantification of O-GlcNAc protein modification in neutrophils by flow cytometry. Cytometry A 2008;73A:667-672.
Clark AJ, Petty HR. Observation of calcium microdomains at the uropod of living morphologically polarized human neutrophils using flash lamp-based fluorescence microscopy. Cytometry A 2008;73:673-678. Epub 2008 May 21.
Elner VM, Park S, Cornblath W, Hackel R, Petty HR. Flavoprotein autofluorescence detection of early ocular dysfunction. Arch Ophthalmol 2008;126:259-260.
Hinkovska-Galcheva VT, Clark A, Van Way SM, Huang JB, Hiraoka M, Abe A, Borofsky M, Kunkel RG, Shanley TP, Shayman JA, Lanni F, Petty HR, Boxer LA. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J Lipid Res 2008;49:531-542. Epub 2007 Dec 21.
Zhu A, Huang JB, Clark A, Romero R, Petty HR. 2,5-Deoxyfructosazine, a d-glucosamine derivative, inhibits T-cell interleukin-2 production better than d-glucosamine. Carbohydr Res 2007 [Epub ahead of print].
Yang D, Elner SG, Bian ZM, Till GO, Petty HR, Elner VM. Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 2007;85:462-472. Epub 2007 Jun 27.
Jarvis JN, Jiang K, Petty HR, Centola M. Neutrophils: The forgotten cell in JIA disease pathogenesis. Pediatr Rheumatol Online J 2007;5:13.
Huang JB, Clark AJ, Petty HR. The hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells. Cell Immunol 2007;245:1-6. Epub 2007 May 3.
Petty HR. Fluorescence microscopy: Established and emerging methods, experimental strategies, and applications in immunology. Microsc Res Tech 2007;70:687-709. Epub 2007 March 28.
Kummer U, Zobeley J, Brasen J, Fahmy R, Kindzelskii A, Petty A, Clark AJ, Petty HR. Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach. Biophys J 2007;92:2597-2607. Epub 2007 Jan 19.
Sitrin RG, Emery SL, Sassanella TM, Blackwood RA, Petty HR. Selective localization of recognition complexes for leukotriene B4 and formyl-Met-Leu-Phe within lipid raft microdomains of human polymorphonuclear neutrophils. J Immunol 2006;177:8177-8184.
Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 2006;8:R154.
Kindzelskii AL, Clark AJ, Espinoza J, Maeda N, Aratani Y, Romero R, Petty HR.Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy. Eur J Immunol 2006;36:1619-1628.
Adachi Y, Kindzelskii AL, Petty AR, Huang JB, Maeda N, Yotsumoto S, Aratani Y, Ohno N, Petty HR. IFN-gamma primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking.
J Immunol 2006;176:5033-5040.
Petty HR, Kindzelskii AL, Espinoza J, Romero R. Trophoblast contact deactivates human neutrophils. J Immunol 2006;176:3205-3214.
Elner SG, Petty HR, Elner VM, Yoshida A, Bian ZM, Yang D, Kindezelskii AL. TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression. Trans Am Ophthalmol Soc 2005;103:126-135; discussion 135-137.
Huang JB, Espinoza J, Romero R, Petty HR. Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women. Metabolism 2006;55:279-281.
Petty HR. Spatiotemporal chemical dynamics in living cells: from information trafficking to cell physiology. Biosystems 2006;83:217-224.
Kindzelskii AL, Petty HR. Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses.
Eur Biophys J 2005 Dec;35(1):1-26.
Elner SG, Petty HR, Elner VM, Yoshida A, Bian ZM, Yang D, Kindzelskii AL. TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression. Invest Ophthalmol Vis Sci 2005;46:4627-3463.
Petty HR, Kindzelskii AL, Chaiworapongsa T, Petty AR, Romero R.Oxidant release is dramatically increased by elevated glucose concentrations in neutrophils from pregnant women. J Matern Fetal Neonatal Med 2005;18:397-404.
Vasireddy V, Vijayasarathy C, Huang J, Wang XF, Jablonski MM, Petty HR, Sieving PA, Ayyagari R. Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes. Mol Vis 2005;11:665-676.
Huang JB, Espinoza J, Romero R, Petty HR. Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy.
Metabolism 2005;54:1027-1033.
Hinkovska-Galcheva V, Boxer LA, Kindzelskii A, Hiraoka M, Abe A, Goparju S, Spiegel S, Petty HR, Shayman JA. Ceramide 1-phosphate, a mediator of phagocytosis. J Biol Chem 2005;280:26612-2621.
Clark AJ, Petty HR. Differential intracellular distributions of inositol trisphosphate and ryanodine receptors within and among hematopoietic cells. J Histochem Cytochem 2005;53:913-916.
Zareparsi S, Buraczynska M, Branham KE, Shah S, Eng D, Li M, Pawar H, Yashar BM, Moroi SE, Lichter PR, Petty HR, Richards JE, Abecasis GR, Elner VM, Swaroop A. Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet 2005;14:1449-1455.
Rosenspire AJ, Kindzelskii AL, Simon BJ, Petty HR. Real-time control of neutrophil metabolism by very weak ultra-low frequency pulsed magnetic fields. Biophys J 2005;88:3334-3347.
Petty HR. Dynamic chemical instabilities in living cells may provide a novel route in drug development. Chembiochem 2004;5:1359-1364.
Kindzelskii AL, Elner VM, Elner SG, Yang D, Hughes BA, Petty HR. Human, but not bovine, photoreceptor outer segments prime human retinal pigment epithelial cells for metabolic activation and massive oxidant release in response to lipopolysaccharide and interferon-gamma. Exp Eye Res 2004;79:431-435.
Kindzelskii AL, Elner VM, Elner SG, Yang D, Hughes BA, Petty HR. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol 2004;124:139-149.
Kindzelskii A, Petty HR. Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes. Eur Biophys J 2004;33:291-299.
Kindzelskii AL, Ueki T, Michibata H, Chaiworapongsa T, Romero R, Petty HR. 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase form a supramolecular complex in human neutrophils that undergoes retrograde trafficking during pregnancy. J Immunol 2004;172:6373-6381.
Kindzelskii AL, Sitrin RG, Petty HR. Cutting edge: optical microspectrophotometry supports the existence of gel phase lipid rafts at the lamellipodium of neutrophils: apparent role in calcium signaling. J Immunol 2004;172:4681-4685.
Huang JB, Kindzelskii AL, Clark AJ, Petty HR. Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: their apparent roles in cell motility and invasion. Cancer Res 2004;64:2482-2489.
Kindzelskii AL, Amhad I, Keller D, Zhou MJ, Haugland RP, Garni-Wagner BA, Gyetko MR, Todd RF 3rd, Petty HR. Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator. Histochem Cell Biol 2004;121:299-310.
Huang JB, Takeda Y, Araki Y, Sendo F, Petty HR. Molecular proximity of complement receptor type 3 (CR3) and the glycosylphosphatidylinositol-linked protein GPI-80 on neutrophils: effects of cell adherence, exogenous saccharides, and lipid raft disrupting agents. Mol Immunol 2004;40:1249-1256.
Sitrin RG, Johnson DR, Pan PM, Harsh DM, Huang J, Petty HR, Blackwood RA. Lipid raft compartmentalization of urokinase receptor signaling in human neutrophils. Am J Respir Cell Mol Biol 2004;30:233-241.
Petty HR. Detection of cytokine signal transduction "cross-talk" in leukocyte activation. Methods Mol Biol 2004;249:219-228.
Albrecht E, Kindzelskii AL, Petty HR. Signal processing times in neutrophil activation: dependence on ligand concentration and the relative phase of metabolic oscillations. Biophys Chem 2003;106:211-219.
Yoshida A, Elner SG, Bian ZM, Kindezelskii AL, Petty HR, Elner VM. Activated monocytes induce human retinal pigment epithelial cell apoptosis through caspase-3 activation. Lab Invest 2003;83:1117-1129.
Elner SG, Elner VM, Kindzelskii AL, Horino K, Davis HR, Todd RF 3rd, Glagov S, Petty HR. Human RPE cell lysis of extracellular matrix: functional urokinase plasminogen activator receptor (uPAR), collagenase and elastase. Exp Eye Res 2003;76:585-595.
Worth RG, Kim MK, Kindzelski AL, Petty HR, Schreiber AD. Signal sequence within FcgRIIA controls calcium wave propagation patterns: Apparent role in phagolysosome fusion. Proc Natl Acad Sci U S A 2003;100:4533-4538.
Elner VM, Elner SG, Bian ZM, Kindezelskii AL, Yoshida A, Petty HR. RPE CD14 immunohistochemical, genetic, and functional expression. Exp Eye Res 2003;76:321-331.
Olsen LF, Kummer U, Kindzelski AL, Petty HR. A Model of the Oscillatory Metabolism of Activated Neutrophils. Biophys J 2003;84:69-81.
Kindzelski AL, Petty HR. Intracellular Calcium Waves Accompany Neutrophil Polarization, fMet-Leu-Phe Stimulation and Phagocytosis: A High-Speed Microscopy Study. J Immunol 2003;170:64-72.
Kindzelski AL, Huang JB, Chaiworapongsa T, Kim YM, Romero R, Petty HR. Pregnancy Alters Glucose-6-Phosphate Dehydrogenase Trafficking, Cell Metabolism and Oxidant Release of Maternal Neutrophils. J Clin Invest 2002;110:1801-1811.
Rosenspire AJ, Kindzelski AL, Petty HR. Cutting Edge: Febrile Temperatures Dramatically Enhance Local Oxidant Release by Adherent Neutrophils in Response to Lipopolysaccharide. J Immunol 2002;169:5396-5400.
Kindzelski AL, Petty HR. Apparent Role of Traveling Metabolic Waves in Periodic Oxidant Release by Living Cells. Proc Natl Acad Sci U S A 2002;99:9207-9212.
Petty HR. Oscillatory signals in migrating neutrophils: effects of time-varying chemical and electrical fields. In: Self-Organized Biological Dynamics and Nonlinear Control by External Stimuli. (J. Walleczek, ed.). Cambridge University Press (Cambridge, UK), 2001 (pp. 173-192).
Sitrin RG, Pan PM, Blackwood RA, Huang JB, Petty HR. Cutting Edge: Evidence for a signaling partnership between urokinase receptors (CD87) and L-selectin (CD62L) in human polymorphonuclear neutrophils. J Immunol 2001;166:4822-4825.
Petty HR, Kindzelski, AL. Dissipative metabolic patterns respond during neutrophil transmembrane signaling. Proc Natl Acad Sci U S A 2001;98:3145-3149.
Kindzelski AL, Petty HR. Extremely low frequency electric fields promote neutrophil extension, metabolic resonance and DNA damage during migration. Biochim Biophys Acta 2000;1495:90-111.
Jiang Q, Miyake K, Petty HR. Cutting Edge: A lipopolysaccharide-induced physical association between CD14 and Toll-like receptor 4 (TLR4) precedes NF-kB translocation to the nucleus. J Immunol 2000;165:3541-3544.
