Bret A. Hughes, Ph.D.
Publications
Pattnaik BR, Hughes BA. Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. Am J Physiol Cell Physiol 2009 Jul 29. [Epub ahead of print]
Yang D, Zhang X, Hughes BA. Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium. Exp Eye Res 2008;87:176-183. Epub 2008 May 28.
Yang D, Swaminathan A, Zhang X, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. Exp Eye Res 2008;86:81-91.
Hughes BA, Swaminathan A. Modulation of the Kir7.1 potassium channel by extracellular and intracellular pH. Am J Physiol Cell Physiol 2008;294:C423-431. Epub 2007 Dec 19.
Yang D, Swaminathan A, Zhang X, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. Exp Eye Res 2008;86:81-91.
Yang D, Swaminathan A, Zhang X, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. Exp Eye Res 2007 [in press].
Mandal MN, Vasireddy V, Jablonski MM, Wang X, Heckenlively JR, Hughes BA, Reddy GB, Ayyagari R. Spatial and temporal expression of MFRP and its interaction with CTRP5. Invest Ophthalmol Vis Sci 2006;47:5514-5521.
Mandal MN, Vasireddy V, Reddy GB, Wang X, Moroi SE, Pattnaik BR, Hughes BA, Heckenlively JR, Hitchcock PF, Jablonski MM, Ayyagari R. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006;47:5505-5513.
Kindzelskii AL, Elner VM, Elner SG, et al. Human, but not bovine, photoreceptor outer segments prime human retinal pigment epithelial cells for metabolic activation and massive oxidant release in response to lipopolysaccharide and interferon-gamma. Exp Eye Res 2004;79:431-435.
Kindzelskii AL, Elner VM, Elner SG, et al. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol 2004;124:139-149.
Ocheltree SM, Keep RF, Shen H, et al. Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes. Pharm Res 2003;20:1364-1372.
Yang D, Pan A, Swaminathan A, Kumar G, Hughes BA. Expression and localization of the inwardly rectifying K+ channel Kir7.1 in native bovine retinal pigment epithelium. IOVS 2003;44:3178-3185.
Yang D, Ernst SA, MacCallum DA, Hughes BA. Expression of the inwardly rectifying K+ channel Kir2.1 in native bovine corneal endothelial cells. IOVS 2003;44:3511-3519.
Yuan Y, Shimura M, Hughes BA. Regulation of inwardly rectifying K+ channels in retinal pigment epithelial cells by intracellular pH. J Physiol (Lond) 2003;549:429-438.
Shimura M, Yuan Y, Chang JT, Zhang S, Campochiaro PA, Zack DJ, Hughes BA. Expression and permeation properties of the K+ channel Kir7.1 in the retinal pigment epithelium. J Physiology 2001;531:329-346.
Hughes BA, Kumar GA, Swaminathan A, Yan D, Yuan Y, Sharma A, Plumley L, Yang-Feng TL, Swaroop A. Cloning and functional expression of human retinal Kir2.4, a pH-sensitive, inwardly rectifying K+ channel. Amer J Physiol Cell 2000;279: C771-C784.
Hughes BA, Takahira M. ATP-dependent regulation of the inwardly rectifying K current in bovine retinal pigment epithelial cells. Amer J Physiol 1998;275;C1372-C1383.
Takahira M, Hughes BA. Isolated bovine retinal pigment epithelial cells express delayed rectifier- and M-type potassium currents. Amer J Physiol 1997;273:C1-C14.
Hughes BA, Takahira M. Inwardly rectifying K+ currents in isolated human retinal pigment epithelial cells. IOVS 1996;37:1125-1139.
Hughes BA, Takahira M, Segawa Y. An outwardly rectifying K+ current active near resting potential in human retinal pigment epithelial cells. Amer J Physiol 1995;269:C179-187.
Hughes BA, Shaikh A, Ahmad A. Effects of Ba2+ and Cs+ on apical membrane K+ conductance in toad retinal pigment epithelium. Amer J Physiol 1995;268:C1164-1172.
Segawa Y, Hughes BA. Properties of the inwardly rectifying K+ conductance in the toad retinal pigment epithelium. J Physiol (Lond) 1994;476:41-53.
Hughes BA, Segawa Y. cAMP-activated chloride currents in amphibian retinal pigment epithelial cells. J Physiol (Lond) 1993;466:746-76.
