Philip J. Gage, Ph.D.
Publications

• Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA. AP-2{alpha} knockout mice exhibit optic cup patterning defects andfailure of optic stalk morphogenesis. Hum Mol Genet 2010;19:1791-1804. Epub 2010 Feb 11.
• Acharya M, Lingenfelter DJ, Huang L, Gage PJ, Walter MA. Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. J Biol Chem 2009;284:34829-34838. Epub 2009 Oct 2.
• Gage PJ, Zacharias AL. Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. Dev Dyn 2009;238:2149-2162.
• Gage PJ, Qian M, Wu D, Rosenberg KI. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 2008;317:310-324. Epub 2008 Mar 4.
• Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M. Myocardial pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res 2008 2008;102:813-822. Epub 2008 Feb 21.
• Honore AL , Coulon V, Marcil A, Lebel M, Lafrance-Vanasse J, Gage PJ, Camper S, Drouin J. Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol 2007 [in press].
• Asai-Coakwell M, Backhouse C, Casey RJ, Gage PJ, Lehmann OJ. Reduced human and murine corneal thickness in an Axenfeld-Rieger syndrome subtype. Invest Ophthalmol Vis Sci 2006;47(11):4905-4909.
• Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol 2006;296:437-449.
• Sclafani AM, Skidmore JM, Ramaprakash H, Trumpp A, Gage PJ, Martin DM. Nestin-Cre mediated deletion of Pitx2 in the mouse. Genesis 2006;44:336-344.
• Diehl AG, Zareparsi S, Qian M, et al. Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Invest Ophthalmol Vis Sci 2006;47:1785-1793.
• Nowotschin S, Liao J, Gage PJ, et al.Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development 2006;133:1565-1573.
• Zhang HZ, Degar BA, Rogoulina S, et al. Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp Hematol 2006;34:167-178.
• Berry FB, Lines MA, Oas JM, et al.Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum Mol Genet 2006;15:905-919.
• Gage PJ, Rhoades W, Prucka SK, Hjalt T.Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci 2005;46:4200-4208.
• Evans, AL, Gage, PJ. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet 2005;14:3347-3359.
• Kieusseian A, Chagraoui J, Kerdudo C, et al. Expression of Pitx2 in stromal cells is required for normal hematopoiesis. Blood 2006;107:492-500.
• Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ.PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol 2005;19:1893-1903.
• Martin DM, Skidmore SM, Philips ST, et al. PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain. Dev Biol 2004;267(1):93-108.
• Martin DM, Skidmore JM, Fox SE, et al. PITX2 distinguishes subtypes on terminally differentiated neurons in the developing mouse neuroepithelium. Dev Biol 2002;252:84-99.
• Suh H, Gage PJ, Camper SA. PITX2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development 2002;129:329-337.
• Gage PJ, Suh H, Camper SA. Dosage requirement of PITX2 for development of multiple organs. Development 1999;126:4643-4651.
• Gage PJ, Suh H, Camper SA. The bicoid-related PITX gene family in development. Mamm Genome 1999;10:197-200.
• Gage PJ, Camper SA. Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. Hum Mol Genet 1997;6:457-464.